| Hoogenraad Lab Webpage | Protein trafficking and synapse function |
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Introduction The primary goal of the lab is to understand how intracellular protein trafficking underlies neuronal development and function. This work is significant because neurons are dependent upon very precise localization of proteins to support their ability to send and receive information. Neuronal cells represent a unique model for addressing fundamental questions in molecular and cellular biology. The size, shape and specialized functions of neurons permit analyses of neuronal migration, axon and dendrite outgrowth, and synapse formation and function. By understanding the basic cellular mechanisms and development of individual neurons, we can better understand how the nervous system develops and functions in an entire animal. |
2010 * In Press: Mixed microtubules steer dynein-driven cargo transport into dendrites in Current Biology * In Press: Rab4 effector GRASP-1 coordinates membrane maturation of recycling endosomes in PLoS Biology * Jan: Axon extension occurs independently of centrosomal microtubule nucleation in Science click here
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2009 * Nov: Casper Hoogenraad selected as EMBO Young Investigator 2009 click here * Nov: Samantha Spangler successfully defended her PhD thesis. * Oct: Control of neuronal polarity and plasticity in Trends in Cell Biology click here * Oct: Hormonal regulation of AMPA receptor trafficking in Frontiers in Synaptic Neuroscience click here * Sept: Bjorn Dortland successfully defended his PhD thesis. * Aug: Basic mechanisms for recognition and transport of synaptic cargos in Molecular Brain click here * March: Corticosterone alters AMPA Receptor mobility in PLoS ONE click here * March: EBs control persistent microtubule growth in J Cell Biol click here * Jan: Dynamic microtubules regulate dendritic spine morphology in Neuron click here
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2008 * Dec: Ruud Toonen, Jeroen Pasterkamp and Casper Hoogenraad received a 5 year ZonMW TOP grant. * Nov: Multimerization-driven Ase1 localization in vitro and in vivo in Current Biology click here * Aug: Karin Boekhoorn received a 3 year NWO-ZonMW VENI grant. click here * June: Novel ALS mouse model with impaired dynein/dynactin function in Hum Mol Genetics click here * April: Eva Teuling successfully defended her PhD thesis. click here * Febr: Mutant SOD1 in neurons triggers neuronal degeneration in J Neurosci click here * Febr: Plus-end tracking proteins in differentiated cells in Int J Biochem Cell Biol click here
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2007 * Dec: Lukas Kapitein received a 3 year NWO-ALW VENI grant. click here * Oct: Liprin proteins: scaffold molecules for synapse maturation Review Article click here * Sept: Reduced levels of VAP cause neuronal degeneration Cover Article in J Neurosci click here |
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Last update: Jan 10, 2010 |
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